Core gum contains chewing gum base, containing butylated hydroxy toluene (E321), xylitol, peppermint oil, anhydrous sodium carbonate, acesulfame potassium, levomenthol, light magnesium oxide, quinoline yellow AI lake (E104), talc A risk-benefit assessment should be made by an appropriate healthcare professional for patients with the following conditions: Nicorette Icy White 4mg Gum, Nicorette® Fruitfusion 4mg Gum, Nicorette® Freshmint 4mg Gum, Nicorette® 4mg Gum Progressive severity of renal impairment is associated with decreased total clearance of nicotine. Nicotine clearance was on average decreased by 50%, in subjects with severe renal impairment. Raised nicotine levels have been seen in smokers undergoing hemodialysis. Nicorette® Inhalator works to relieve cravings and nicotine withdrawal symptoms associated with a dependence on tobacco. It s a form of Nicotine Replacement Therapy (NRT) that provides a low level of nicotine to help reduce withdrawal symptoms without any of the tar, carbon monoxide and other chemicals contained in tobacco smoke.

Nicorette ® Microtabs only come in one strength but vary in dosage depending on your daily smoking habits: Phaeochromocytoma and uncontrolled hyperthyroidism: As nicotine causes release of catecholamines, this product should be used with caution in patients with uncontrolled hyperthyroidism or phaeochromocytoma. All products are developed to meet Pharmaceutical standards and the highest possible quality. Quit smoking and help break the habit with Nicorette. Nicorette contains nicotine. Stop smoking aid or stop nicotine vaping aid. Requires willpower. Always read the label. Nicorette Cools 2mg lozenge is used to relieve/and or prevent withdrawal symptoms and reduce the cravings you get when you try to stop smoking or when cutting down the number of cigarettes you smoke. However it can be used in a number of different ways, either to completely replace all your cigarettes, or if you do not feel ready to stop smoking completely, to replace certain cigarettes and therefore help you to cut down the number of cigarettes you smoke. It may also help increase your motivation to quit. Requires willpower.

The patient should make every effort to stop smoking or vaping completely during treatment with this product. Danger in children: Doses of nicotine tolerated by adult and adolescent smokers or vapers can produce severe toxicity in children that may be fatal. Products containing nicotine should not be left where they may be misused, handled or ingested by children. See Section 4.9 Overdose.

Coating contains Hypromellose (methocel E3), winterfresh flavour, titanium dioxide (E171), sucralose (E955), sepifilm gloss, acesulfame potassium (E950) , polysorbate 80, purified water The primary metabolite of nicotine in plasma, cotinine, has a half-life of 15 to 20 hours and concentrations that exceed nicotine by 10-fold. Nicotine metabolism and elimination are independent of the choice of nicotine formulation, and thus results from studies with intravenous administration of nicotine are used to describe biotransformation and elimination. Nicorette® are at the forefront of Nicotine Replacement Therapy (NRT) innovation, offering a range of products to suit your needs including, nicotine gum, nicotine patches, nicotine inhalators and nicotine chewing gum to help you to quit smoking.

Stopping smoking: Polycyclic aromatic hydrocarbons in tobacco smoke induce the metabolism of drugs metabolised by CYP 1A2 (and possibly by CYP 1A1). When a smoker stops smoking, this may result in slower metabolism and a consequent rise in blood levels of such drugs. This is of potential clinical importance for products with a narrow therapeutic window, e.g. theophylline, clozapine and ropinirole. Nicotine should be avoided during breast-feeding. The relatively small amounts of nicotine found in breast milk during NRT use are less hazardous to the infant than second-hand smoke. Intermittent dose forms would minimize the amount of nicotine in breast milk and permit feeding when levels were at their lowest. Underlying cardiovascular disease: In stable cardiovascular disease this product presents a lesser hazard than continuing to smoke. However dependent smokers currently hospitalised as a result of myocardial infarction, unstable or worsening angina including Prinzmetal's angina, severe dysrhythmia or cerebrovascular accident and who are considered to be haemodynamically unstable and/or who have uncontrolled hypertension should be encouraged to stop smoking with non-pharmacological interventions. If this fails, this product may be considered, but as data on safety in this patient group are limited, initiation should only be under medical supervision. The risks of continued vaping are not yet established. After priming, point the spray nozzle as close to the open mouth as possible. Press the top of the dispenser and release one spray into your mouth, avoiding the lips. Do not inhale while spraying to avoid getting spray down your throat. For best results, do not swallow for a few seconds after spraying.

Patients willing or able to stop smoking/vaping immediately should initially replace all their cigarettes/e-cigarettes with this product and as soon as they are able, reduce the number of sprays used until they have stopped completely. A parallel, double-blind, placebo-controlled, randomised pharmacodynamic study conducted in solus, regular vapers has shown that the mouth spray is effective in relieving momentary urges to vape (cravings) following ad lib use of the spray over 11 hours. A significantly higher proportion of subjects (p<0.001) in the mouth spray group (82.6%) had a maximum reduction of at least 50% vs. baseline in momentary urges-to-vape scores during the two hours follow-up compared to the placebo group (55.1%).

Lozenge – Suitable if you smoke 20 cigarettes or less per day. Available in both Nicorette® Cools and Nicorette® Fruit Lozenges.

The oral spray form means that the nicotine dose is administered instantaneously, and as a result the absorption of nicotine from the mouth spray is rapid: In trials, nicotine uptake from the oral nicotine spray was detected at 2 minutes, the first timepoint tested. GI disease: Nicotine may exacerbate symptoms in patients suffering from oesophagitis, gastritis or peptic ulcers and NRT preparations should be used with caution in these conditions.

You are more likely to quit smoking/vaping when using this product with help from your pharmacist, doctor, a trained counsellor or a support programme. Although the frequency in the active group is less than that of the placebo group, the frequency in the specific formulation in which the PT was identified as a systemic ADR was greater in the active group than the placebo group. You can use Nicorette® Inhalators to completely replace all your cigarettes, to cut down, or to calm cravings at times where you can t or don t want to smoke (such as in smoke-free areas).